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Post by micgrow on Oct 14, 2012 19:18:12 GMT -5
Dr. A,
How serious is a concern is renal issues with common oral antibiotics when dealing with more serious infections? For instance azithromycin is often prescribed at 1g and over for some infections. If a patient has no history of Kidney issues, is a treatment exceeding 1g PO OD a serious concern for long term kidney function?
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Post by arcticfox on Oct 15, 2012 13:11:39 GMT -5
Dr. A, How serious is a concern is renal issues with common oral antibiotics when dealing with more serious infections? For instance azithromycin is often prescribed at 1g and over for some infections. If a patient has no history of Kidney issues, is a treatment exceeding 1g PO OD a serious concern for long term kidney function? Azithromycin can be given at up to 2 gm per day for a normal size adult so it shouldn't cause any problems at all if you took it below 2 gm. Even if your dose did exceed 2 gm slightly.. it shouldn't be a big deal. With a few exceptions, most of the commonly prescribed drugs (especially OTC meds) are dosed with a fairly large safety margin in mind. That way even if you exceed the recommended dose slightly, you would be fine. The two exceptions being NSAID and Tylenol. The main concern with these two is that people take them so commonly and often ignore the recommended dose when dealing with acute or chronic pain. In addition these drugs are often included in other OTC medication already and patients often do not add up the total dose. The organ of damage is often the organ where the drug is metabolized. So for NSAID it is excreted through kidney while tylenol it is through liver. This is why NSAID like ibuprofen can cause renal failure in high doses. And Tylenol can cause liver failure if taken in doses far exceeding the typical 4 g per day limit. For Azithromycin, the metabolism is through the liver and the metabolite is excreted via bile. So it shouldn't cause much problem to your kidney especially considering the dose that you mentioned wasn't that much to begin with. Looks like LD50 for oral dose of Azithromycin is around 4g/kg for rats. That means it takes 4 gram of the drug to kill a theoretical giant 1 kg rat, 50% of the time! Assuming the data holds for human. It would take a single dose of 280 gm to have a 50% chance of killing a 70 kg average size man. In other words, Azithromycin is a relatively safe drug with low toxicity.
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Post by joefarina on Oct 15, 2012 13:12:49 GMT -5
HEY ARCTIC....WHAT CAN YOU PRESCRIBE FOR KODAK???
HOW WAS YOUR HOT DATE THERE CUTIE??
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Post by micgrow on Oct 17, 2012 18:52:11 GMT -5
Thank you for taking the time to respond. My research concurs but I always confirm from multiple outlets before considerings it fact. Much appreciated.
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